Online il nostro studio sul Microbiota intestinale nei gemelli monozigoti discordanti per la malattia di Parkinson

B&M riprende le Newsletter scientifiche con il nuovo Studio condotto da Fondazione Grigioni per il Morbo di Parkinson e dal Centro Parkinson di Milano, pubblicato su  Annals of Neurology, relativo al microbiota intestinale nei gemelli monozigoti discordanti per la malattia di Parkinson.

 

Abstract
Differences in gut microbiota between Parkinson's disease patients and controls seem to depend on multiple—frequently unmeasured—confounders. Monozygotic twins offer a unique model for controlling several factors responsible for interpersonal variation in gut microbiota. Fecal samples from 20 monozygotic twin pairs (n = 40) discordant for Parkinson's disease were studied (metagenomic shotgun analysis). Paired data analysis detected minimal differences in bacterial taxa abundance at species level (Bacteroides pectinophilus [p = 0.037], Bifidobacterium pseudocatenulatum [p = 0.050], and Bifidobacterium catenulatum [p = 0.025]) and in predicted metabolic pathways (primary bile acid biosynthesis [p = 0.037]). Additional studies are warranted to understand the role of gut microbiota in the pathogenesis of Parkinson's disease.
 

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